Effects of endothelin-11-31 on cell viabililty and [Ca
نویسندگان
چکیده
Department of Physiology, College of Basic Medical Sciences, Second Military Medical University,Shanghai,PR China 2 Department of Cardiovasology, Changhai Hospital, Shanghai,PR China 3 School of Beaic Medical Science, Ning-Xia Medical College, Yinchuan, PR China These authors contributed equally to this paper *Corresponding author. Phn/Fax 86-21-2507-4367. Email:[email protected] or [email protected]
منابع مشابه
Effects of endothelin-1 1-31 on cell viabililty and [Ca2+]i in cultured neonatal rat cardiomyocytes.
We previously found that endothelin-1(1-31) (ET-1(1-31)) exhibited a pro-arrhythmogenic effect in isolated rat hearts. In this study, we further investigated the effects of ET-1(1-31) on a cell viability and observed [Ca(2+)](i) in cultured cardiomyocytes. Cultured neonatal rat cardiomyocytes were treated with 0.1, 1, and 10 nM ET-1(1-31) for 24h in the presence or absence of ET(A) receptor ant...
متن کاملEndothelin-1 decreases [Ca]i via Na/Ca exchanger in CHO cells stably expressing endothelin ETA receptor
Endothelin ETA receptor couples to Gq/11 protein that transduces a variety of receptor signals to modulate diverse cellular responses including Ca mobilization. Stimulation of endothelin ETA receptor with endothelin-1 is generally believed to induce an increase in intracellular Ca concentration ([Ca]i) via Gq/11 protein. Here we provide the first convincing evidence that endothelin-1 elicited G...
متن کاملThe Effect of Resistance Training on Plasma Levels of Endothelin 1 and Blood Pressure in Older Men
Introduction: Endothelin 1, which is secreted by vascular endothelial cells, has been identified as the most potent vasoconstrictor. The purpose of this study was to investigate the effect of a course of endothelin-1 plasma resistance training and its relationship with blood pressure in older men. Methods: In this quasi-experimental study, 30 elderly men (mean age 62.28 ± 8.08 years, height 17...
متن کاملInterplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy
Objective(s): The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy. Results:In present study Endothelin treated car...
متن کاملComparative Evaluation of Immunohistochemical Expression of Endothelin A Receptor between Oral Squamous Cell Carcinoma and Normal Oral Mucosa
Background: Recent research has provided evidences indicating the importance of endothelin axis in carcinogenesis. According to our knowledge, there are little information about endothelin A receptor (ETA) expression in oral squamous cell carcinoma (OSCC). So, the aim of the present study was to evaluate the immunohistochemical expression of ETA in OSCC and normal oral mucosa (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007